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Eric2015-02-05 16:19:192015-09-21 07:21:27HcpResearch articles and Reviews
2024
GldX
Zammit M., Bartoli J., Kellenberger C., Melani P., Roussel A., Cascales E., Leone P. 2024. Structure-function analysis of PorXFj, the PorX homolog from Flavobacterium johnsioniae, suggests a role of the CheY-like domain in type IX secretion motor activity. Sci Rep. 14, 6577.
PMID: 38503809
Type 1 fimbriae
Dessartine M.M., Kosta A., Doan T., Cascales E., Côté J.-P. 2024. Type 1 fimbriae-mediated collective protection against type 6 secretion system attacks. mBio. 0, e02553-23.
PMID: 38497656
Stenotrophomonas T6SS
Garin T., Brin C., Préveaux A., Brault A., Briand M., Simonin M., Barret M., Journet L., Sarniguet A. 2024. The type VI secretion system of Stenotrophomonas rhizophila CFBP13503 limits the transmission of Xanthomonas campestris pv. campestris 8004 from radish seeds to seedlings. Mol Plant Pathol. 25, e13412.
PMID: 38279854
MiMB – Supernatant
Flaugnatti N, Journet L. 2024. Identification of effectors: precipitation of supernatant material. Methods Mol Biol. 2715, 533-538.
PMID: 37930549
MiMB – TAP
Viala JPM, Bouveret E. 2024. Protein-protein interaction: Tandem Affinity Purification in bacteria. Methods Mol Biol. 2715, 285-297.
PMID: 37930536
MiMB – BACTH TM
Zoued A, Duneau JP, Cascales E. 2024. Bacterial One- and Two-Hybrid assays to monitor transmembrane helix interactions. Methods Mol Biol. 2715, 259-271.
PMID: 37930534
MiMB – Peptidoglycan
Santin YG, Cascales E. 2024. Measure of peptidoglycan degradation activity. Methods Mol Biol. 2715, 197-205.
PMID: 37930529
MiMB – Proteolysis
Chabalier M, Doan T, Cascales E. 2024. Probing protein topology and conformation by limited proteolysis. Methods Mol Biol. 2715, 111-119.
PMID: 37930525
2023
Young Minds
Cascales E. 2023. Crossbow, murder hole, poison and grenade: the deadly arsenal of bacteria. Front Young Minds. 11, 1193114.
PMID: not yet indexed
Fitness
Taillefer B, Giraud JF, Cascales E. 2023. No fitness cost entailed by type VI secretion system synthesis, assembly, contraction, or disassembly in enteroaggregative Escherichia coli. J Bacteriol. 205, e0035723.
PMID: 37971272
MuF
Bartoli J, Tempier AC, Guzzi NL, Piras CM, Cascales E, Viala JPM. 2023. Characterization of a (p)ppApp synthetase belonging to a new family of polymorphic toxin associated with temperate phages. J Mol Biol. 435, 168282.
PMID: 37730083
PAAR
Beauvois SG, Flaugnatti N, Ilbert M, Boyer M, Gavello-Fernandez E, Fronzes R, Jurenas D, Journet L. 2023. The tip protein PAAR is required for the function of the type VI secretion system. Microbiol Spectr. 6, e0147823.
PMID: 37800964
MFE01 amidase
Bourigault Y, Dupont CA, Desjardins JB, Doan T, Bouteiller M, Le Guenno H, Chevalier S, Barbey C, Latour X, Cascales E, Merieau A. 2023. Pseudomonas fluorescens MFE01 delivers a putative type VI secretion amidase that confers biocontrol against the soft-rot pathogen Pectobacterium atrosepticum. Environ Microbiol. 25, 2564-2579.
PMID: 37622480
LAGA and SAGK methods
2023. Qualitative and quantitative methods to measure antibacterial activity resulting from bacterial competition. Bio-Protocol. 13, e4706.
PMID: 37449039
T9SS effector review
2023. A journey with type IX secretion system effectors: selection, transport, processing and activities. Microbiology. 169, 001320.
PMID: 37043368
AIEC T6SS Tle3 phospholipase
2023. Activity and crystal structure of the adherent-invasive Escherichia coli Tle3/Tli3 T6SS effector/immunity complex determined using an AlphaFold2 predicted model. Int J Mol Sci. 24, 1740.
PMID: 36675258
T6SS MC-BP interaction
2023. Coevolution-guided mapping of the type VI secretion membrane complex-baseplate interface. J Mol Biol. 435, 167918.
PMID: 36509161
2022
EF-Tu-targeting toxin
2022. Salmonella antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of EF-Tu P-loop. Nucleic Acids Res. 50, 13114-13127.
PMID: 36484105
Bacillus T7SS YukC
2022. The antibacterial type VII secretion system of Baciluus subtilis: structure and interactions of the pseudokinase YukC/EssB. mBio. 13, e0013422.
PMID: 36154281
T9SS cryo-ET
Song L., Perpich J.D., Wu C.G., Doan T., Nowakowska Z., Potempa J. Christie P.J., Cascales E., Lamont R. Hu B. 2022. A unique bacterial secretion machinery with multiple secretion centers. Proc Natl Acad Sci USA. 119, e2119907119.
PMID: 35471908
This study and the work on the GldLM molecular motor have been featured on the CNRS website (in French): le T9SS, une mitrailleuse à 8 canons !
GldLM Motor
Vincent M.S., Comas Hervada C., Sebban-Kreuzer C., Le Guenno H., Chabalier M., Kosta A., Guerlesquin F., Mignot T., McBride M.J., Cascales E., Doan T. 2022. Dynamic proton-dependent motors power type IX secretion and gliding motility in Flavobacterium. PLOS Biology. in press
PMID: 35333857
PorN structure
Fuchsbauer O., Lunar Silva I., Cascales E., Roussel A., Leone P. 2022. Structural and functional analyses of the Porphyromonas gingivalis type IX secretion system PorN protein. J Biol Chem. 298, 101618.
PMID: 35065963
PorW-Sov interaction
Gorasia D.G., Lunar Silva I., Butler C.A., Chabalier M., Doan T., Cascales E., Veith P.D., Reynolds E.C. 2022. Protein interactome analysis of the type IX secretion system identifies PorW as the missing link between the PorK/N ring complex and the Sov translocon. Microbiol. Spectrum. 10, e0160221.
PMID: 35019767
T9SS JDR Review
Veith P.D., Glew M.D., Gorasia D.G., Cascales E., Reynolds E.C. 2022. The T9SS system and its role in bacterial function and pathogenesis. J Dent Res. 101, 374-383.
PMID: 34889148
TiM Spotlight
Jurenas D., Cascales E. 2022. T6SS: killing two bugs with one stone. Trends Microbiol. 30, 1-2.
Commentary on Le et al. Proc Natl Acad Sci USA. 118, e2106555118.
PMID: 34753653
2021
Rhs structure
Jurenas D., Talachia Rosa L., Rey M. Chamot-Rooke J., Fronzes R., Cascales E. 2021. Mounting, structure and autocleavage of a Type VI secretion-associated Rhs polymorphic toxin. Nat Commun. 12, 6998.
PMID: 34853317
This work has been feratured on the CNRS website (in French): Rhs, une grenade antibactérienne.
Myxococcus Predation
Seef S., Herrou J., de Boissier P., My L., Brasseur G., Robert D., Jain R., Mercier R., Cascales E., Habermann B.H., Mignot T. 2021. A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria. eLife. 10, e72409.
PMID: 34505573
Azospirillum T6SS
Cassán F.D., Coniglio A., Amavizca E., Maroniche G., Cascales E., Bashan Y., de-Bashan L.E. 2021. The Azospirillum brasilense type VI secretion system promotes cell aggregation, biocontrol protection against phytopathogens and attachment to the microalgae Chlorella sorokiniana. Environ Microbiol. 23, 6257-6274.
PMID: 34472164
Photo-ART-Tox
Jurenas D., Payelleville A., Roghanian M., Turnbull K.J., Givaudan A., Brillard J., Hauryliuk V., Cascales E. 2021. Photorhabdus antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of 23S ribosomal RNA. Nucleic Acids Res. 49, 8384-8395.
PMID: 34255843
TagL-3D
Nguyen V.S., Spinelli S., Cascales E., Roussel A., Cambillau C., Leone P. 2021. Anchoring the T6SS to the cell wall: Crystal structure of the peptidoglycan-binding domain of the TagL accessory protein. PLOS ONE. 16, e0254232.
PMID: 34214145
Porphyromonas Review
Lunar Silva I., Cascales E. 2021. Molecular strategies underlying Porphyromonas gingivalis virulence. J. Mol. Biol. 433, 166836.
PMID: 33539891
T6SS Effector Review
Jurenas D., Journet L. 2021. Activity, delivery and diversity of type VI secretion effectors. Mol. Microbiol. 115, 383-394.
PMID: 33217073
2020
VgrG-Tle1
Flaugnatti N., Rapisarda C., Rey M., Beauvois S.G., Nguyen V.A., Canaan S., Durand E., Chamot-Rooke J., Cascales E., Fronzes R., Journet L. 2020. Structural basis for loading and inhibition of a T6SS phospholipase by the VgrG spike. EMBO J. 39, e104129.
PMID: 32350888
This work has been highlighted on Sarah’s blog on bacterial communication and competition. Click to read !
Fur-Dam
Brunet Y.R., Bernard C.S., Cascales E. 2020. Fur-Dam regulatory interplay at an internal promoter of the enteroaggregative Escherichia coli Type VI secretion sci1 gene cluster. J Bacteriol. 202, e00075-20.
PMID: 32152218
2019
Prox Labeling Review
Santin Y.G. 2019. Uncovering the in vivo proxisome using proximity-tagging methods. Bioessays. 41, e1900131
PMID: 31664723
Tail length
Santin Y.G., Doan T., Journet L., Cascales E.. 2019. Cell width dictates Type VI secretion tail length. Curr. Biol. 29, 3707-3713
PMID: 31630952
T6SS-Review ASM
Cherrak Y., Flaugnatti N., Durand E., Journet L., Cascales E.. 2019. Structure and activity of the type VI secretion system. Microbiol. Spectr. 7, PSIB-0031-2019
PMID: 31298206
Cover
The T6SS is on the cover of the June issue of Journal of Bacteriology !
TagL
Santin Y.G., Camy C.E., Zoued A., Doan T., Aschtgen M.S., Cascales E.. 2019. Role and recruitment of the TagL peptidoglycan-binding protein during Type VI secretion system biogenesis. J. Bacteriol. 201, e00173-19
PMID: 30910811
Cover
The T6SS is on the cover of the May issue of The EMBO Journal !
Cryo-EM TssJLM
Rapisarda C., Cherrak Y., Kooger R., Schmidt V., Pellarin R., Logger L., Cascales E., Pilhofer M., Durand E., Fronzes R. 2019. In situ and high-resolution cryo-EM structure of a bacterial Type VI secretion system membrane complex. EMBO J. 38, e100886
PMID: 30877094
2018
T6SS baseplate wedge
Cherrak Y., Rapisarda C., Pellarin R., Bouvier G., Bardiaux B., Allain F. Malosse C., Rey M., Chamot-Rooke J., Cascales E., Fronzes R., Durand E. 2018. Biogenesis and structure of a Type VI secretion baseplate. Nat. Microbiol. 3, 1404-1416 .
PMID: 30323254
see the Behind the paper “Building the blocks of a bacterial weapon” by Chiara.
Cover
The T6SS is on the cover of the November issue of Nature Microbiology.
APEX-TagA
Santin Y.G., Doan T., Lebrun R., Espinosa L., Journet L., Cascales E. 2018. In vivo proximity labelling during Type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheath. Nat. Microbiol. 3, 1304-1313 .
PMID: 30275513
see the Behind the paper “The Type VI secretion system under tension” by Yoann.
see the CNRS press release here
see the News and Views “Tagging the Type VI secretion system” by Olivera Francetic.
Hcp-VgrG
Renault M.G., Zamarreno Beas J., Douzi B., Chabalier M. Zoued A., Brunet Y.R., Cambillau C., Journet L., Cascales E. 2018. The gp27-like hub of VgrG serves as adaptor to promote Hcp tube assembly. J. Mol. Biol. 430, 3143-3156.
PMID: 30031895
TssL-TM
Zoued A., Duneau J.P., Durand E., Espana A.P., Journet L., Guerlesquin F., Cascales E. 2018. Tryptophan-mediated dimerization of the TssL transmembrane anchor is required for Type VI secretion system activity. J. Mol. Biol. 430, 987-1003.
PMID: 29458124
Review TiM
Chassaing B., Cascales E. 2018. Antibacterial weapons: targeted destruction in the microbiota. Trends Microbiol. 26, 329-338.
PMID: 29452951
Review COSB
Nguyen V.S., Douzi B., Durand E., Roussel A., Cascales E., Cambillau C. 2018. Towards a complete structural deciphering of Type VI secretion system. Curr. Opin. Struct. Biol. 49, 77-84.
PMID: 29414515
PorM structure
Leone P., Roche J., Vincent M.S., Tran Q.H., Desmyter A., Cascales E., Kellenberger C., Cambillau C., Roussel A. 2018. Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasm space. Nat. Commun. 9, 429.
JMB TssB Cter
Douzi B., Logger L., Spinelli S., Blangy S., Cambillau C., Cascales E. 2018. Structure-function analysis of the C-terminal domain of the Type VI secretion TssB tail sheath subunit. J. Mol. Biol. 430, 297-309.
2017
Commentary Amoebophilus
Cascales E. 2017. Microbiology: and Amoebophilus invented the machine gun ! Curr Biol. 27, 1170-1173.
see the original article by Böck et al. here
Bioessays – TssA
Zoued A., Durand E., Santin Y.G., Journet L., Roussel A., Cambillau C., Cascales E. 2017. TssA: the cap protein of the Type VI secretion system tail. Bioessays. 39, 1600262
MiMB – Supernatant
Flaugnatti N., Journet L. 2017. Identification of effectors: precipitation of supernatant material. Methods Mol Biol. 1615, 459-464.
MiMB – Complex purification
Durand E., Lloubès R. 2017. Large Complexes: Cloning Strategy, Production, and Purification. Methods Mol Biol. 1615, 299-309.
MiMB – TMH interactions
Logger L., Zoued A., Cascales E. 2017. Fusion Reporter Approaches to Monitoring Transmembrane Helix Interactions in Bacterial Membranes. Methods Mol Biol. 1615, 199-210.
MiMB – PG degradation
Santin Y.G., Cascales E. 2017. Measure of Peptidoglycan Hydrolase Activity. Methods Mol Biol. 1615, 151-158.
MiMB – Proteolysis
Vincent M.S., Cascales E. 2017. Probing Inner Membrane Protein Topology by Proteolysis. Methods Mol Biol. 1615, 97-103.
TssK structure
Nguyen V.S., Logger L., Spinelli S., Legrand P., Huyen Pham T.T., Nhung Trinh T.T., Cherrak Y., Zoued A., Desmyter A., Durand E., Roussel A., Kellenberger C., Cascales E., Cambillau C. 2017. Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex. Nat Microbiol. 2, 17103.
see the CNRS press release here
T3SS secret chamber
Cascales E. 2017. Inside the chamber of secrets of the Type III secretion system. Cell. 168, 949-951.
see the original article by Hu et al. here
T9SS PorKLMN complex
Vincent M.S., Canestrari M.J., Leone P., Stathopulos J., Ize B., Zoued A., Cambillau C., Kellenberger C., Roussel A. & Cascales E. 2017. Characterization of the Porphyromonas gingivalis Type IX secretion trans-envelope PorKLMNP core complex. J Biol Chem. 292, 3252-3261.
2016
The T6SS LTG
Santin Y.G. & Cascales E. 2017. Domestication of a housekeeping transglycosylase for assembly of a Type VI secretion system. EMBO Rep. 18, 138-149.
ClpV-TssC interaction
Douzi B., Brunet Y.R., Spinelli S., Lensi V., Legrand P., Blangy S., Kumar A., Journet L., Cascales E. & Cambillau C. 2016. Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli. Sci Rep. 6, 34405.
Cover
The T6SS is on the cover of the November issue of Journal of Molecular Biology !
TssLc domain
Zoued A., Cassaro C.J., Durand E., Douzi B., Espana A.P., Cambillau C., Journet L. & Cascales E. 2016. Structure-function analysis of the TssL cytoplasmic domain reveals a new interaction beween the Type VI secretion baseplate and membrane complexes. J Mol Biol. 428, 4413-4423.
TssMc domain
Logger L., Aschtgen M.S., Guérin M., Cascales E. & Durand E. 2016. Molecular dissection of the interface between the Type VI secretion TssM cytoplasmic domain and the TssG baseplate component. J Mol Biol. 428, 4424-4437.
PorXY TCS
Vincent M.S., Durand E. & Cascales E. 2016. The PorX response regulator of the Porphyromonas gingivalis PorXY two-component system does not directly regulate the Type IX secretion genes but binds the PorL subunit. Front Cell Infect Microbiol. 6, 96.
Salmonella Attacks !
Sana T., Flaugnatti N., Lugo K.A., Lam L.L., Jacobson A., Baylot V., Durand E., Journet L., Cascales E. & Monack D.M. 2016. S. Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut. Proc Natl Acad Sc. USA. 113, 5044-5051.
see the CNRS press release here
This article has been recommended by Eugene Nester on F1000
TssA is a tail coordinator
Zoued A., Durand E., Brunet Y.R., Spinelli S., Douzi B., Guzzo M., Flaugnatti N., Legrand P., Journet L., Fronzes R., Mignot T., Cambillau C. & Cascales E. 2016. Priming and polymerization of a bacterial contractile tail. Nature. 531, 59-63.
PMID: 26909579
see the CNRS press release here
This article has been recommended by Chris Whitfield on F1000
Baeza meeting report
Aussel L., Beuzón C.R., & Cascales E. 2016. Meeting report: adaptation and communication of bacterial pathogens. Virulence. 7, 481-490.
PMID: 26890494
T6SS phospholipase effector
Flaugnatti N., Le TT., Canaan S., Aschtgen MS., Nguyen VS., Blangy S., Kellenberger C., Roussel A., Cambillau C., Cascales E. & Journet L. 2016. A phospholipase A1 antibacterial type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery. Mol Microbiol. 99, 1099-1118.
PMID: 26714038
2015
T6SS baseplate identification
Brunet Y.R., Zoued A., Boyer F., Douzi B. & Cascales E. 2015. The Type VI secretion TssEFGK-VgrG phage-like baseplate is recruited to the TssJLM membrane complex via multiple contacts and serves as assembly platform for tail tube/sheath polymerization. PLOS Genetics. 11, e1005545.
Biogenesis and structure of the T6SS membrane complex
Durand E., Nguyen V.S., Zoued A., Logger L., Pehau-Arnaudet G., Aschtgen M.S., Spinelli S., Desmyter A. Bardiaux B., Roussel A., Cambillau C., Cascales E. & Fronzes R. 2015. Biogenesis and structure of a Type VI secretion core membrane complex. Nature. 523, 555-560.
see the CNRS press release here
H-NS regulation of Salmonella T6SS
Brunet Y.R., Khodr A., Logger L., Aussel L., Mignot T., Rimsky S., and Cascales E. 2015. H-NS silencing of the SPI-6-encoded Type VI secretion system limits Salmonella enterica serovar Typhimurium interbacterial killing. Infect Immun. 83, 2738-2750.
TssM-specific nanobody competes with T6SS
Nguyen VS, Logger L., Spinelli S., Desmyter A., Han Lè TT, Kellenberger C., Douzi B., Durand E., Roussel A., Cascales E., and Cambillau C. 2015. Inhibition of Type VI secretion by an anti-TssM llama nanobody. PLOS ONE. 10, e0122187.
PorM crystallization
Stathopulos J., Cambillau C., Cascales E., Roussel A. and Leone P. 2015. Crystallization and preliminary X-ray analysis of the C-terminal fragment of PorM, a subunit of the Porphyromonas gingivalis Type IX secretion system. Acta Crystallogr F Struct Biol Commun. 71, 71-74.
TssM-specific nanobodies
Nguyen VS, Spinelli S., Desmyter A., Han Lè T.T., Kellenberger C., Cascales E., Cambillau C. and Roussel A. 2015. Production, crystallization and X-ray diffraction analysis of a complex between a fragment of the TssM T6SS protein and a camelid antibody. Acta Crystallogr F Struct Biol Commun. 71, 266-271.
2014
PLoS Genetics 2014 e1004869.
Gueguen E., Wills N.M., Atkins J.A., and Cascales E. 2014. Transcriptional frameshiting rescues Citrobacter rodentium Type VI secretion by the production of two length variants from the prematurely interrupted tssM gene. PLoS Genetics. 10, e1004869.
Trends Microbiol
Durand E., Cambillau C., Cascales E., and Journet L. 2014. VgrG, Tae, Tle and beyond: the versatile arsenal of Type VI secretion effectors. Trends Microbiol. 22, 498-507. (Review)
Biochem. Biophys Acta Mol Cell Res
Zoued A., Brunet Y.R., Durand E., Aschtgen M.-S., Logger L., Douzi B., Journet L., Cambillau C., and Cascales E. 2014. Architecture and assembly of the Type VI secretion system. Biochem. Biophys Acta Mol Cell Res. 1843, 1664-1673. (Review)
Escherichia coli. PLOS ONE
Douzi B., Spinelli, S., Blangy S., Roussel A., Durand E., Brunet Y.R., Cascales E., and Cambillau C. 2014. Crystal structure and self-interaction of the Type VI secretion tail-tube protein from enteroaggregative Escherichia coli. PLOS ONE. 9, e86918.
EMBO Rep
Brunet Y.R., Hénin J., Célia H., and Cascales E. 2014. Type VI secretion and bacteriophage tail tubes share a common assembly pathway. EMBO Rep. 15, 315-321.
2013
PLOS ONE 2013 e81074
Zhang X.Y., Brunet Y.R., Logger L., Douzi B., Cambillau C., Journet L. and Cascales E. 2013. Dissection of the TssB-TssC interface during Type VI secretion sheath complex formation. PLOS ONE. 8, e81074.
J. Biol. Chem 2013 27031-27041
Zoued A., Durand E., Bebeacua C., Brunet Y.R., Douzi B., Cambillau C., Cascales E. and Journet L. 2013. TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane-anchoring complexes of the Type VI secretion system. J. Biol. Chem. 288, 27031-27041.
PLOS ONE 2013 e66615
Gueguen E., Durand E., Zhang X.Y., d’Amalric Q., Journet L. and Cascales E. 2013. Expression of a Yersinia pseudotuberculosis Type VI secretion system is responsive to envelope stresses through the OmpR transcriptional activator. PLOS ONE. 8, e66615.
Cell Rep
Brunet Y.R., Espinosa L., Harchouni S., Mignot T. and Cascales E. 2013. Imaging bacterial Type VI secretion-dependent killing. Cell Rep. 3, 36-41.
see the CNRS press release here
Appl. Environ. Microbiol.
Gueguen E. and Cascales E. 2013. Promoter swapping unveils the role of the Citrobacter rodentium CTS1 Type VI secretion system for inter-bacterial competition. Appl. Environ. Microbiol. 79, 32-38.
2012
J Biol Chem 2012 38190-38199
Durand E., Derrez E., Audoly G., Spinelli S., Ortiz-Lombardia M., Raoult D., Cascales E., and Cambillau C. 2012. Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae Type VI secretion system. J Biol Chem. 287, 38190-38199.
Ann. Rev. Microbiol
Silverman J.M., Brunet Y.R., Cascales E., and Mougous J.D. 2012. Structure and regulation of the Type VI secretion system. Ann. Rev. Microbiol. 66, 453-472. (Review)
J. Biol. Chem 2012 14157-14168
Durand E., Zoued A., Spinelli S., Watson P.J., Aschtgen M.-S., Journet L., Cambillau C. and Cascales E. 2012. Structural characterization and oligomerization of the TssL protein, a component shared by the bacterial Type VI and Type IVb secretion systems. J. Biol. Chem. 287, 14157-14168.
MicrobiologyOpen
Aschtgen M.-S., Zoued A., Lloubès R., Journet L., and Cascales E. 2012. The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC. MicrobiologyOpen. 1, 71-82.
Cover
The T6SS is on the cover of Philosophical Transactions of the Royal Society !
Phil. Trans. R. Soc. B
Cascales E. and Cambillau C. 2012. Structural biology of Type VI secretion systems. Phil. Trans. R. Soc. B. 367, 1102-1111. (Review)
2011
PLoS Pathogens
Felisberto-Rodrigues C., Durand E., Aschtgen M.S., Blangy S., Ortiz-Lombardia M., Douzi B., Cambillau C. and Cascales E. 2011. Towards a structural comprehension of bacterial Type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathogens. 7, e1002386.
PLoS Genetics 2011 e1002205
Brunet Y.R., Bernard C.S., Gavioli M., Lloubès R., and Cascales E. 2011. An epigenetic switch involving overlapping Fur and DNA methylation optimizes expression a Type VI secretion gene cluster. PLoS Genetics. 7, e1002205.
J Bacteriol 2011
Bernard C.S., Brunet Y.R., Gavioli M., Lloubès R., and Cascales E. 2011. Regulation of Type VI secretion gene clusters by 54 and cognate enhancer binding proteins. J Bacteriol. 193, 2158-2167.
2010
Virulence
Aschtgen M.S., Thomas M.S., and Cascales E. 2010. Anchoring the Type VI secretion system to the cell wall: TssL, TagL, TagP, TagN,… What else? Virulence 1, 535-540.
Escherichia coli
Aschtgen M.-S., Gavioli M., Dessen A., Lloubès R., and Cascales E. 2010. The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall. Mol Microbiol. 75, 886-899.
This article has been highlighted in Faculty of 1000 and has been the object of an Addendum in Virulence (Aschtgen et al. Virulence 1, 535-540).
J Bacteriol 2010
Bernard C.S., Brunet Y.R., Gueguen E., and Cascales E. 2010. Nooks and crannies in Type VI secretion regulation. J Bacteriol. 192, 3850-3860. (Review).
2008
Escherichia coli. J Bacteriol
Aschtgen M.-S., Bernard C.S., de Bentzmann S., Lloubès R., and Cascales E. 2008. SciN is an outer membrane lipoprotein required for Type VI secretion in enteroaggregative Escherichia coli. J Bacteriol. 190, 7523-7531.
EMBO Rep
Cascales E. 2008. The Type VI secretion tool kit. EMBO Rep. 9, 735-741.
Publications
TreX2 December 2024 - 14 h 37 min
GldX20 March 2024 - 14 h 36 min
Type 1 fimbriae19 March 2024 - 21 h 38 min
Stenotrophomonas T6SS10 January 2024 - 22 h 41 min