After graduating in the laboratory of Roland Lloubès in 2002, I moved to Houston (Texas) for a wonderful stay in Pete Christie’s lab where I discovered the world of bacterial secretion systems. Back to Marseille, I launched the team on Type VI secretion. Although I love these nano-machines, I spend most of my time playing violin, listening opera, barocco violin and Glass’s Einstein on the beach, hiking to find wild orchids or kayaking or rowing in the calanques ! Who said I am monomaniac?
I performed my graduate studies in Aix-Marseille University in the group of Roland Lloubès (LISM, CNRS). My PhD thesis focused on the Tol/Pal proteins and colicin import. In 2001, I joined the laboratory of Guy Cornelis for a post-doc (in Brussels, then Basel) to study Type III secretion in Yersinia, focusing on the Type III needle length control. After six years in Strasbourg in Isabelle Schalk’s group, studying iron uptake in Pseudomonas aeruginosa, I came back to Marseille and bacterial secretion at the end of 2010 to join Eric’s group to study Type VI secretion. Besides the lab (in the “real life”) I like music, performing theater and not talking too much about myself !
After a baccalaureate in Literature I moved to Science and graduating as a laboratory technician. Passionated by microbiology and specially by the molecular deciphering of bacterial life, pathogenic mechanisms and behaviour, I started my PhD studies. This was my first encounter and the beginning of a career-standing “love story” with bacterial secretion machineries. I studied “type II secretion system” for 7 years, then “type IV secretion system” for 4 years in the group of Gabriel Waksman, and finally 5 years ago I’ve started studying the fascinating “type VI secretion system”. My investigations on these molecular nanomachines range from molecular microbiology to structural biology. I developed a passion for multiscale and integrated structural biology, working with X-rays, SAXS, and EM/cryo-EM techniques. I find very exciting to study the molecular architecture and function of these machineries. One of few things that drives my head away from this passion is when I go on the sea, in the middle of gusty wind and big waves to kitesurf… Only there I can lose myself…
Most of my scientific work has been dedicated to Bacillus subtilis. I used this model bacterium to study carbon metabolism during my PhD with Stéphane Aymerich and bacterial cell biology during my post-doc in David Rudner’s lab before I moved to Marseille in 2009 to work with Anne Galinier. That’s until 2017 when the god of secretion told me it was heresy and that 6 and 9 were the numbers at the origins of life. It will be tremendously hard to leave B. subtilis behind, but I am very motivated by this new challenge and the scientific and technical exchanges with my new colleagues. From sheep embryogenesis during my undergraduate training to bacterial cell biology and secretion machineries, the common trait of my scientific work is my love for picturing small things. This is also true when I am out of the lab. When traveling, hiking, or simply playing with the kids, my camera is always nearby. More keywords about me can be found in this picture (gift from Jen, a friend in the Rudner lab).
After a superior technician diploma in Biochemistry in Marseille, I was hired at the CNRS in the group of Pierre Capy at Paris Sud / Saclay. There, I studied the mariner transposon in the fruit fly Drosophila. I then decided to return back to the sun and to change both the theme and model of my research. I joined the group of Sam Dukan at the Mediterranean Institute of Microbiology to study the impact of CO2 on the oxidative stress in Escherichia coli. I then moved for a short period in the group of Amel Latifi to develop a new biosensor. Finally, I joined the group of Eric to study the Type VI and IX secretion systems. I am afraid of not having much to say, but I always enjoy the life !
I leaved Reims to perform my undergraduate studies in biology in Marseille (first initiation to heat shock). During my PhD, done next door to the Cascales lab, I accidentally had fun with a T6SS component. Then I fall down into the « secretion system world ». So I imposed myself in the team for my post-doc and Eric nicely gave me a subject to play with. Out of the lab … Is there a life out of the lab ?? Some scientists tell tales about calanques, but it must be a legend.
My post-doctoral work is funded by the association “Espoir contre la Mucoviscidose“. You can help the association here.
Fascinated by the molecular mechanisms occurring in bacteria, my ongoing Ph.D work is focused on the characterization of the T9SS. Besides my interest in cellular microbiology, I try to play jazz music. But, as I can’t rid of false notes, I should have best chances to enhance the knowledge of bacterial molecular mechanisms than become the new Miles Davis… So much the better for all!
I performed my undergraduate studies in Biology in the University of Seville (Spain). After a master degree in Microbiology working with yeast, I decided to come to Marseille and to join Eric’s lab to learn everything I can about secretion systems in bacteria. I like Marseille a lot : the different cultures, the beach, the mild weather (I come from a city with 40 degrees on summer under the shadow!). And as soon as I can, I like to hike in the calanques and to do sunbathe in these beautiful places.
Hey! How are you? I’m supposed you’re here to know more about us ! I was raised in Marseille, maybe the best city in France for a tanning session on a beautiful beach! I went to a Bioengineering/Biotechnology school called Polytech Marseille during which I have met Eric Cascales who introduced me the Type VI secretion system. Few months later, I became a PhD working on this topic (pretty hard to resist the appeal of Type VI secretion, trust me!). Apart from work, I’m a synthetic biology fan and have participated to the iGEM competition in 2015. I love sport, traveling, hanging out with friends, and…eating a damn good kebab! My dream? Once found, travelling all around the world with my beloved! I stop here, you know too much about me !
Best quote: “Success is being able to move from failure to failure without loosing one’s enthusiasm”
Despite the fact I am from Corsica, I do not sleep a lot… Why? Because I am too busy to sharpen my knives in order to eat saucisson ! After a Master 2 diploma in Microbiology, I started my PhD in Eric’s lab. Besides, I have handyman skills, so if you need some help with your computer or a door, I am your man ! Outside the laboratory, I maintain my military past (you now understand my haircut…) making hiking and bushcraft with my best friends. Even I am sure it is wrong… people in the lab say I speak a lot, so hang on !
I started to study biology at the University of Franche-Comté and ended up in Strasbourg with a master degree in molecular genetics. Then, I got a second one in human pathologies in Marseille (city which I felt in love with) where I performed mass spectrometry. After a time of incubation I joined Eric’s team to be part of the research focused on bacterial secretion systems. As supplementary data, I play racket sports (mostly badminton but ping pong and tennis also), I like backing (cheesecake, applepie…) and practicing the piano (the black and white keys instrument).
(Ph.D Université Paul Sabatier, Toulouse, France; Post-doctoral fellow A. Darwin’s laboratory, NYC, USA). Now an Associate professor at the Université Claude Bernard (Lyon, France).
Ph.D 2011. Thesis entitled “Etude du système de sécrétion de type VI chez Escherichia coli enter-agrégatif. Caractérisation d’un sous-complexe d’ancrage membranaire”.
Post-doctoral fellow, Ned Ruby laboratory (Madison, USA).
Post-doctoral fellow, Birgitta Henriques-Normark laboratory (Stockholm, Sweden).
Assistant professor at the ‘Laboratoire des Sciences de l’Environnement Marin‘ (LEMAR) at the University of Brest (France).
Now, Assistant professor at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Yannick R. Brunet.
Ph.D 2013. Thesis entitled “Structure and function of the type VI secretion system tail”.
Now a post-doctoral fellow in David Rudner’s laboratory (Harvard Medical School, Boston, USA).
Ph.D 2015. Thesis entitled “Biogenesis and membrane anchoring of the type VI secretion contractile tail”.
Now a post-doctoral fellow in Matthew Waldor‘s laboratory (Harvard Medical School, Boston, USA).
Ph.D 2017. Thesis entitled “The type VI secretion membrane complex: the central role of TssM for assembly and for baseplate recruitment”.
Ph.D 2018. Thesis entitled “Le système de sécrétion de type VI: caractérisation et mécanisme de transport de Tle1, un effecteur antibactérien de type phospholipase”.
Now a post-doctoral fellow in Melanie Blokesch‘s laboratory (EPFL, Lausanne, Switzerland).
Xiang Y. Zhang.
(2011-2013). Ph.D. Now a Research Lecturer at the University of Xi’an (China).
B.Sc. and M. Sc undergraduates.
Yannick Brunet (B.Sc., 2008)
Marie Guérin (M1, 2010)
Abir Benzegoutta (M1, 2010)
Abdelrahim Zoued (M1, 2010)
Quentin d’Amalric (M1, 2011)
Delphine Prévost (ESIL-PolyTech, 2011)
Abdelrahim Zoued (M.Sc., 2011)
Valentin Tutagata (BTS, 2012)
Laureen Logger (M1, 2012)
Seddik Harchouni (B.Sc.(L3), 2012)
Valentine Lensi (L2, 2012)
Charlotte Gaviard (B.Sc., 2012)
Laureen Logger (M.Sc., 2012)
Lia Freier (B.Sc. Erasmus, Tuebingen Univ., Germany, 2013)
Jean-Charles Cancel (L2, 2013)
Emma Long (ESIL-PolyTech, 2013)
Guillaume Urbain (M1, 2013)
Aurélie Fosses (M1, 2013)
Yann Dauchy (B.Sc., 2013)
Jordi Zamarreno-Beas (B.Sc., 2013)
Anant Kumar Singh (Indian Research Scholar fellow, 2013)
Mickaël Canestrari (B.Sc., 2013)
Elodie Pagès (ESIL-PolyTech, 2014)
Maxence Vincent (M1, 2014)
Yoann Santin (L2, 2014)
Doriane Delafosse (B.Sc., 2014)
Alexandre Espana (B.Sc., 2014)
Nicolas Flaugnatti (M.Sc., 2014)
Marcus Höring (M.Sc. Erasmus, Regensburg Univ., Germany, 2014)
Corentin Baussier (L1 Bio, 2015)
Sam Cascales (3ème, 2015)
Kevin Arnould (ESIL-PolyTech, 2015)
Sarah Tjaden (Visiting PhD, Münster, Germany, 2015 & 2016)
Vincent Palomo (L2, 2015)
Tristan Pommier (B.Sc., 2015)
Maxence Durand (3ème, 2015)
Hugo Perez (3ème, 2016)
Chakib Khenafra (L1, 2016)
Alexis Dogliani (M1, 2016)
Viet Anh Nguyen (M.Sc., USTH, Vietnam, 2016)
Chloé Cassaro (L2, Glascow, Scotland, 2016)
Mathias Gallique (Visiting Ph.D, Evreux, 2016)
Wanassa Béroual (B.Sc., 2016)
Théo Dubois (2de, 2017)
Stéphane Alibar (M1, 2017; M2, 2018)
Melvin Renault (B.Sc., 2017)
Claire Camy (B.Sc., 2017)
Camille Garcia (M2, 2018)
Romain Debiton (B.Sc., 2018)
Ryan Ellison (University of Oxford, Laidlaw scholar, 2018)
Mehdi Zouanbi (L3, 2018)
Victoria Sgoluppi (L3, 2018)