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News

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Where to meet us ? Future meetings

30 november-02 December 2021

Eric will give a Plenary lecture at the annual meeting of the Chilean Society for Microbiology.

04-09 september 2022

Eric will give a talk at the BacNet22 workshop in Sant Feliù de Guixols (Spain).

18-23 September 2022

Eric will give the Keynote Lecture at the Plasmid Biology meeting in Toulouse (France).

24-28 September 2022

Eric will give a talk at the Bacterial Protein Export meeting in Leuven (Belgium).

03-04 November 2022

Eric will give a talk at the Microbiology Society meeting on Protein Secretion at the Host-Pathogen Interface in Belfast (Northern Ireland, UK)

Recent news from the lab

06 May 2022

Solène, Boris and Yvann presented their PhD works at the 2022 JSM3 meeting. Well done guys !

28 April 2022

The works on the function of the GldLM molecular motor and on the T9SS cryo-tomography structure have been featured on the CNRS website (in French): le T9SS, une mitrailleuse à 8 canons !

https://www.cascaleslab.fr/wp-content/uploads/2022/04/374189_1_vid_0_qyr66s.mp4
20 March 2022

Congratulations Thierry for your Habilitation thesis ! Great past work and exciting projects !!

25 February 2022

Farewell party for Dukas ! It was great to have you the last 3 years ! We will miss you so much ! But let’s continue our common projects !

13-21 February 2022

Visit of our collaborators in Santiago de Chile ! Exciting to talk about the work done and to discuss our projects with Carlos and his labmates (Blondel’s lab, Universidad Andrés Bello) . Thank you Carlos et al for hosting !

25 January 2022

Congratulations to Dukas for being awarded an ESCMID grant with Thierry ! New and exciting projects in perspectives !

20 January 2022

Farewell party for Julius ! It was great to have you in the lab !
Wait ??? This is picture of the end of the party 🙂

09 December 2021

Our work on the Photorhabdus Rhs activity, loading and structure has been featured on the CNRS website (in French): Rhs, une grenade antibactérienne.

02 December 2021

Dukas presented his recent results on Photorhabdus Rhs activity, structure and mode of delivery at the Microbiology Meeting organized by the Master 2 microbiology students of Aix-Marseille University.

01 December 2021

Eric gave a Plenary lecture at the Annual meeting of the Chilean Society of Microbiology (SoMiCh).

26 November 2021

Gauthier gave a talk on Pseudomonas PA14 PAPI-1 ICE, regulation, transfer and function at the IMM Days.

23 November 2021

Congratulations Yoann for being a recipient of the prestigious Prix des Jeunes Chercheurs of the Fondation Bettencourt-Schueller !

15 October 2021

Dukas gave a great talk on T6SS Rhs toxins at the FNRS Molecular Bacteriology annual meeting in Louvain-la-Neuve (Belgium). Photo by Régis Hallez.

01 October 2021

Eric gave a (online) talk on T6SS architecture and assembly at the University of Sherbrooke (Canada).

19 July 2021

Welcome to Julius, a ERASMUS Master degree student from the Life Sciences Center at Vilnius University, Lituania ! Julius worked on T6SS in the group of Edita Sužiedėlienė in the Department of Biochemistry and Molecular Biology.

01 July 2021

Congratulations Ignacio for your Ph.D defense ! You did it great !

28 June 2020

Congratulations to Maëlle for succeeding to the doctoral school competition ! Ready to start your thesis ? We look forward for your discoveries on T9SS !

23 June 2021

Eric gave a (virtual) conference on T6SS at the University of Sao Paulo (Brasil).

15 June 2021

Welcome to our two summer interns from Aix-Marseille University: Sophie, Floriane, Noa, Pierre and Julien.

19 May 2021

Welcome to Yvann Bourigault (PhD student with Xavier Latour in Evreux) for a short-term visit ! Let’s go for fancy microscopy !!

14 May 2021

The ninth baby of the Lab: Ignacio‘s dissertation ! Congratulations ! Nice Job !

03 May 2021

Eric presented recent works on the T6SS in the Keynote lecture for the University of Texas – Houston Medical School MMG/MID (online) retreat.

19 March 2021

Yoann received the Prix Dina Surdin from the SFBBM for his thesis work on the T6SS.

16 March 2021

Welcome to the Master 1 students for their training period: Margot, Morgane and Jérémy.

19 February 2021

After being postponed twice due to the Covid19 situation, Yoann successfully defending his thesis ! You did an amazing job !

05 February 2021

We have a new technician in the Lab ! Welcome Sophie. Sophie was manager/secretary in an another CNRS Institute dedicated to Nanosciences before deciding to make a U-turn and performing bench work in Microbiology. So, let’s start learning Molecular Biology !

21 December 2020

Eric gave a (virtual) talk at the Wuhan University of Technology (China).

01 October 2020

New arrival in the Lab ! Gauthier is joining us for his post-doc. Gauthier did his Ph.D in Christophe Bordi’s team on the regulation of the Pseudomonas PAPI-1 island. His post-docotal work will be funded by the association ‘Espoir contre la Mucoviscidose‘.  You can support this association by making a donation.

25 September 2020

Congratulations Yassine for defending your thesis ! You did it great !!

14 September 2020

The eigth baby of the Lab: Yoann‘s dissertation ! We look forward for the defense !

17 July 2020

Thank you the ANR for funding our work on the T6SS and T9SS !

09 July 2020

Julie successfully defended her Habilitation ! Congratulations !

04 July 2020

Congratulations to Romain for succeeding to the doctoral school competition ! Ready to start your thesis ? We will learn more on T6SS accessory genes ! Stay tuned !

02 July 2020

The team is now part of the French Bacteriophage Network (Réseau Bactériophage France). We look forward for discussions and new collaborations ! You can follow this Phage group on Twitter.

01 July 2020

Welcome to our two summer interns from Aix-Marseille University: Camille and Jonas.

01 July 2020

The T6SS made the cover at J Bacteriol ! Thank you Annalisa Pierro for the SciArt !

21 April 2020

The seventh baby of the Lab: Yassine‘s dissertation ! Well done !

20 April 2020

Our work on TssA, TagA and tail length control has been featured in an article of Ambre Moreau, Lucas Dupuis, and Donovan Robert, three AMU master 2 students, published in Medecine & Sciences (in French). You can read it here.

15-17 April 2020

Laure and Eric presented the lab latest research at T6SympoZOOM, a virtual T6SS meeting during the Covid-19 lockdown.

April – May 2020

The CNRS supports a webserie  “Diffuse la Science, pas le Virus“,  an initiative of Tâm Mignot and Yann Vacher. Three Ph.D students of the team, Boris, Yassine and Yoann, and Eric participated to six episodes (in French).

Episode 1: La promesse de l’hydroxychloroquine

Episode 2: Les stratégies sociales pour endiguer la pandémie de Covid-19

Episode 3: La sérothérapie pour le Covid-19?

Episode 4: Covid-19: à la quête de l’élixir vaccinal

Episode 5: Repositionnement de médicaments contre le Covid-19

Episode 6: Bilan sur l’hydroxychloroquine

16 March

Lab shutdown due to the Coronavirus SARS-CoV2 pandemic… Hope to see you soon !

01 January 2020

Julie, Julia, Yasmine and Michaël (previously in Emma Bouveret’s group at the LISM) join us ! Very excited to start new projects !

November-December 2019

Three new arrivals in the lab: Welcome to Marie, Caterina and Boris ! Marie (a previous engineer in a biological start-up) and Caterina (previously in WD Hardt’s lab in Zurich, Switerland) join us as engineers, while Boris (a former Master student from Alain Givaudan’s lab in Montpellier and Alice Guidot/Stéphane Génin in Toulouse) join us for his Ph.D !

01-06 September 2019

Ignacio, Yassine and Yoann presented their works at the BacNet19 meeting at Sant Feliù de Guixols.

28 August – 05 September 2019

Dukas participates to the FEMS-MedILS post-doctoral summer school, with other talented and promising young scientists !

07-11 July 2019

Dukas presented his work at the FEMS General meeting in Glascow.

01 July 2019

Welcome to our two summer interns: Ashleigh (Oxford) and Baptiste (Aix-Marseille).

28 June 2019

Solène succeeded to the doctoral school competition. Welcome in the lab for your thesis ! You will tell us how the Tle1 effector is loaded on the T6SS !

01 June 2019

We have a new microscope ! Take your turn to record beautiful images !
Thank you the Fondation Bettencourt-Schueller for financing this racing machine !

22 May 2019

The T6SS made the Cover at J Bacteriol !

20 May 2019

Moving day ! We are moving to a new space. New labs, new offices, new material !

15 May 2019

The T6SSS membrane complex made the Cover in EMBO Journal !

3 May 2019

Laure successfully defended her Habilitation !

25 March 2019

Congratulations to Dr. Maxence Vincent for this impressive Ph.D viva !

11-13 March 2019

Eric presented recent works from the lab at the meeting of the Collaborative Research Center (SFB766) on Bacterial Cell Envelope (Tuebingen, Germany).

21 February 2019

Well done ! Laure‘s Habilitation Dissertation !

07 February 2019

The sixth baby of the lab ! Congratulations Maxence for your dissertation manuscript !

01 February 2019

Welcome to Amaury and Dukas !
Amaury got his PhD from the University of Montpellier (team of Alain Givaudan), working on DNA methylation in Photorhabdus.
Dukas got his PhD from the University of Brussels (Belgium) (team of Laurence Van Melderen/Abel Garcia-Pino), working on toxins/anti-toxins.
They will work together to decipher the role of a T6SS toxin in Photorhabdus !

22 January 2019

Yassine presented a poster on his work on the T6SS baseplate at the 13thannual Salk Fondation/ Ipsen science symposium on biological complexity.

05 January 2019

Yoann‘s article on TagA was awarded “Article of the month” from the Société Française de Biochimie et Biologie Moléculaire (French Society for Biochemistry and Molecular Biology).

10 December 2018

The team was awarded the “Coup d’Elan pour la Recherche Française” of the Fondation Bettencourt Schueller. The ceremony was hold at the Institut de France. Here is the link for the team presentation.

13 November 2018

Eric gave a talk on T6SS for the Microbiology PhD program at the Federal University of Rio (Brazil). (Invited by Leticia Lery).

12 Novembre 2018

Eric gave a talk on T6SS at the Departamento de Microbiologia of the University of Sao Paulo (Brazil) (Invitation by Chuck Farah and Cristina Alvarez Martinez.

07-11 November 2018

Eric presented recent lab works at the Brazilian/French br.BIO.fr meeting, and the satellite RIO International School of Structural Biology.

04-07 November 2018

Eric C. presented recent work on T6SS at the Current Trends in Medicine workshop on “Contribution of Bacterial injection systems in human diseases” in Baeza (Spain).

31 October 2018

Eric gave a talk on T6SS at the Université Libre de Bruxelles (Belgium). (Invited by Laurence Van Melderen).

24 October 2018

TagA helps T6SS to hold their fire. Our work makes the cover of the Nature Microbiology November 2018 issue.

23 October 2018

The work of the lab has been highlighted in the Mathieu Vidard’s chronicle (l’édito carré) at the France Inter radio broadcast “Game of Thrones chez les bactéries” !!

19 October 2018

Ryan presented his summer internship work at the 2018 Laidlaw scholars event, hold at the Sheldonian Theater in Oxford.

11 October 2018

Yoann gave a presentation of his work at the ETMM2018 and received the award for the best talk. Congrats !!

11 October 2018

Group picture at  ETMM2018.
From left to right. Top row: Thierry, Maialène and Etienne. Bottom row: Yoann, Eric C., Ignacio, Laure, Yassine and Maxence. Are missing Eric D. and Victoria

11 October 2018

Laure and Yoann demonstrating unexpected talent during the Karaoke session at ETMM2018 !!

08-12 October 2018

Laure, Thierry, Maialène, Maxence, Ignacio, Yassine, Yoann and Eric C. participated to the Thematic School of Molecular Microbiology (Carry-le-Rouet, France).

02 October 2018

Ignacio and Eric C. presented the work on T9SS and T6SS at the EMBO & FEMS “Bacterial Protein Export” meeting in Leuven (Belgium).

01 October 2018

The identification of the T6SS latch is featured on the CNRS webpage.

09-12 September 2018

Maxence and Yoann participated to the 84th Harden conference on single-molecule bacteriology (Oxford, UK).

04-07 September 2018

Eric D. participated to the ESCMID Conference on Drug Development (Lisbon, Portugal).

12 July 2018

Thank you the ANR for funding two of our projects on Type VI secretion effectors and membrane complex ! Congratulations Laure and Eric D. !!

05 July 2018

Congratulations to Nicolas for his Ph.D defense ! Great work !!

01 June 2018

Welcome to Etienne who joined the lab as engineer for 3 years !

24 May 2018

Congratulations to Maxence who was awarded a Fondation pour la Recherche Médicale 4th year fellowship to pursue his work on T9SS ! Thank you the FRM for supporting us !

17-18 May 2018

Ignacio and Yassine gave talks to present their works at the JSM3 meeting. Maxence and Yoann presented a poster. Yoann was awarded the best poster presentation, and Yassine the best “striptease” (no video for Yassine striptease, sorry !!). The award picture also features Pierre from Stéphane Canaan’s lab, who won the best oral presentation.

14 May 2018

The fifth baby of the lab ! Congratulations Nicolas for your dissertation manuscript !

03 April 2018

The team has been awarded the “Equipe 2018” label from the Fondation pour la Recherche Médicale. Thank you to all the generous funders ! Please make a donation to the FRM by clicking here !

30 March 2018

Maxence presented his work at the Bacterial membrane symposium at the Institut Pasteur (Paris, France). Well done !

26 March 2018

Happy to host Giuseppina Mariano from the Sarah Coulthurst‘s lab ! Great work to identify new players for T6SS effector activation !

20 March 2018

Maxence, Yassine and Yoann participated to the “Challenges and new concepts on antibiotic research” at the Pasteur Institute (Paris, France). From left to right: Yoann, Maxime (from Sophie Bleves’s lab), Maxence and Yassine.

30 January 2018

Happy to host Dukas Jurenas from the laboratory of Laurence van Melderen (Brussels, Belgium) ! Great work on toxin-antitoxin systems !

25 January 2018

Ryan Ellison, an undergraduate student from Exeter College of Oxford University was awarded a Laidlaw scholarship to develop a summer project in our lab ! Congrats Ryan !!

22 January 2018

Eric C. gave a seminar at the Max Planck Institute for terrestrial biology in Marburg (Germany).

03 January 2018

Welcome to the two Master students !
Camille will work with Eric D. in collaboration with Françoise Guerlesquin and Jean-Pierre Duneau from the LISM.
Stéphane will work with Laure.

08 December 2017

Congratulations to Laureen for the defense of her thesis !

06 December 2017

Eric C. gave a lecture on “Guerres Intestines” at the Collège de France (Paris).

28 November 2017

Eric C. gave a plenary lecture at the Japanese IGER International symposium on cell surfaces (Nagoya).

17 November 2017

Eric C. gave the 9th Joel Mandelstam lecture at the University of Oxford (UK).

01 November 2017

Happy to host a new post-doc in the lab ! Welcome Victoria. And thank you the generous funders of Espoir contre la Mucoviscidose for funding Victoria’s work ! Please make donation to the association !

22 October 2017

Thank you the AMIDEX (Initiative of Excellence from Aix-Marseille Université) to fund our project on the assembly of the Type IX secretion system !

19 October 2017

Eric C. gave a plenary lecture at the Belgium Society for Microbiology.

13 October 2017

Here it is: the fourth baby in the lab ! Congrats Laureen for your dissertation manuscript !

01 September 2017

We are happy to have Maïalène and Thierry joining the lab !

15 July 2017

Thank you the ANR for funding our new project (T6-PLATFORM) on the assembly of the Type VI secretion system !

01 July 2017

It is out !!! Laure and Eric C. edited the Methods in Molecular Biology book on “Bacterial protein secretion systems” that includes 36 method chapters to study secretion systems (and other multiprotein machines) !

27-30 June 2017

Maxence and Yassine presented posters at the EMBO Symposium “New Approaches and Concepts in Microbiology“, Heidelberg (Germany).

27 June 2017

The work on the TssK structure and its role in docking the baseplate to the membrane complex is featured on the CNRS website.

23 June 2017

Congratulations to Yoann who obtained a fellowship to continue his work as a Ph.D student !

04 April 2017

Eric C. gave a conference at the Annual UK Microbiology Society (Edinburgh, Scotland, UK)

15 March 2017

Eric C. gave a seminar at the University of Dundee (Scotland, UK)

January 2017

The lab participated to a popularization article on the T6SS for a french magazine for kids “Science et Vie Junior” !

19-20 January 2017

Eric D. gave a talk at the Soleil Users Meeting (SUM 2017), Soleil Synchrotron (France).

27-30 November 2016

Nicolas presented his work on T6SS effector at the EMBO Conference on ‘Bacterial morphogenesis, survival and virulence’. Kerala (India).

09-12 November 2016

Laure and Eric C. represented the lab at the Zing Conference on Protein Transport and Translocation (Tampa, USA).

07-09 November 2016

Eric C. gave plenary lectures at the 3rd French-Brazilian Symposium on Biosciences “br.BIO.fr” (November 07th) and V Latin American Protein Society meeting (November 08-09). Rio de Janeiro (Brazil).

06 November 2016

Very proud of having the T6SS on the Cover of the 2016 November issue of J Mol Biol ! Read our back-to-back papers in the issue and download the Cover !

12 september 2016

Our work in collaboration with Thibault Sana in the group of Denise Monack on the role of the T6SS during Salmonella infection is featured on the CNRS website.

12 July 2016

Rahim is awarded the best 2015 thesis from the Aix-Marseille Université !
Well done !!

30 June 2016

Congratulations to Yassine who obtained a Ph.D fellowship to join the group !

24 June 2016

Rahim received the Dina Surdin Award from the French Society for Biochemistry and Molecular Biology (SFBBM).

21 June 2016

Rahim presented his Ph.D work in the plenary room of the French National Academy of Science.

AdS-ARZ

01 June 2016

We are happy to host Mathias Gallique, a visiting Ph.D studentMathias

from the group of Annabelle Merieau at the University of Evreux / Rouen.

20 May 2016

Logo-INSERM

Eric D. was hired as a “Chargé de Recherche” at the INSERM Waaaooouuuu !!

19 May 2016

IMG_0847-Website

Nicolas presented his work on the T6SS-secreted phospholipase at the JSM3 meeting.

18 May 2016

Laureen obtained a 4th year Ph.D fellowship from the Fondation pour la Recherche Médicale !

22 April 2016

Rahim received the Bettencourt-Schueller Award for his Ph.D work ! Congrats again !!

08 April 2016

Rahim was selected for a présentation at the “Académie des Sciences” (French National Academy of Science) as one of the six major progresses in France in 2015 ! Congrats

see flyer

01 March 2016

Our work on the T6SS tail assembly regulation by TssA is featured on the CNRS website.

24 february 2016

Rahim and Eric celebrate their TssA paper in Nature ! Champagne !TssA-champaign_1000

22 february 2016

Nicolas describes the poison he identified at the extremity of the spike,                                                          at the Huffington Post: ma thèse en deux minutes.

16 February 2016

Rahim has an article in the newspaper “Var matin” !

02 February 2016

Congrats Eric D. for the ESCMID research grant !

30 January 2016

Maxence left for a 5-week stay in Margaret Duncan’s laboratory (Forsyth Institute, Boston, USA).

28-29 January 2016

Laure, Laureen and Maxence were at the Royal Society ‘New bacteriology‘ meeting. London, UK.

07 December 2015

Congrats to Dr. Zoued ! Great PhD defense !

412-OK  415-OK

01 December 2015

Congratulations to Rahim for the SFBBM (French Society for Biochemistry and Molecular Biology) award of the best article of the month (for the TssJLM membrane complex Nature paper) !

26-28 October 2015

Nicolas and Eric C. were at the ‘Adaptation and Communication of Bacterial Pathogens’                   workshop (Universidad International de Andalucia, Baeza, Spain).IMG_0359_1000

Nicolas presented a poster (here with David Low, UCSB).

12 October 2015

Rahim talks about his thesis, at the Huffington Post: ma thèse en deux minutes !

18 september 2015

Laure presented a poster on a EAEC T6SS effector at the 4th Molecular Laure_Vienna_2015_1000

Microbiology meeting in Vienna.

11 September 2015

Press release : our work on the T6SS is featured in Arte Future.

21 August 2015

Our work on the TssJLM membrane complex is featured on the CNRS website.

15 August 2015

Our work on the TssJLM membrane complex is featured in Nature Reviews in Microbiology.

04-08 August 2015

Laureen Logger presents a short talk at the ‘Bacteria and Phage Meeting’ (Madison, USA)

01 August 2015

Marie-Stéphanie hired as Faculty Member at the University of Brest !
Best wishes ! Proud of our Alumni !

29 July 2015

Eric D. and Rahim celebrate their article in Nature !            News-2015-07-29_1000

24 July 2015

We are now on Twitter ! #CascalesLab

22 July 2015

Our paper on the assembly and structure of the T6SS membrane complex is now online on the Nature website !

01 July 2015

Congratulations to Maxence for his Master 2 diploma and the thesis fellowship !

11 June 2015

Congratulation to Laureen for her Award of the ‘Best Oral Presentation’ at the Doctoral School meeting !

07-11 June 2015

Eric C. is presenting the ‘Assembly and structure of the T6SS membrane complex’ at the FEMS meeting in Maastricht (The Netherlands).

14 May 2015

Congratulation to Rahim for his ‘Nature Reviews in Microbiology’ Award of the Best Poster Presentation at the BacNet15 meeting !

09-14 May 2015

Rahim is presenting a poster at the BacNet 2015 meeting at San Feliu de Guixol (Spain).

03 April 2015

Laure, Rahim, Laureen, Nicolas and Maxence are at the Institut Pasteur Symposium on ‘Bacterial Membranes’.

21-25 March 2015

Eric C. is giving a talk at the EMBO Conference on ‘Mechanism and Regulation of Protein translocation’ in Dubrovnik (Croatia).

10 March 2015

Rahim was awarded the Jean-Pierre Ebel Award of the SFBBM – a travel grant to participate to a conference. Let’s go to the BacNet15 meeting !

28 February 2015

We are happy to host Sarah Tjaden, a visiting Ph.D student from the group of Ulrich Dobrindt at the University of Muenster (Germany) until July

01 January 2015

Maxence joined the lab for his Master 2 training work. He will focus his work on the characterization of a T9SS subunit.

23 November 2014

Rahim is leaving the lab for a 4-week training period in Remi Fronzes’s laboratory (Pasteur Institute, Paris).

01 November 2014

12-3.NicolasNicolas is starting his Ph.D. All the best !

10 October 2014

12-2. Rahim-Pipetted'OrRahim was awarded the “gold pipetman” for the best oral presentation at the meeting ! Congrats !

06 October 2014

Laure, Laureen and Rahim are at the “Ecole thématique de Microbiologie” in Carry-le-Rouet (France).

20 September 2014

Eric C. gave a plenary lecture at the latin-american PGPR meeting in Cordoba (Argentina).

05 July 2014

Nicolas succeeded at his Master 2 ! Congratulations !

23 June 2014

Laure and Rahim are at the Gordon Conference on ‘Bacterial Cell Surfaces’ (Vermont, USA).

20 June 2014

Thank you to our three undergraduate trainees, Doriane, Alexandre and Yoann, for the time and efforts in the lab !

14 May 2014

Elodie obtained the best mark for her oral presentation on the work she has done in the lab with Laure ! Not for her performance in Bowling !

07-09 May 2014

Laure and Laureen are at the 3d Molecular Microbiology meeting in Würzburg (Germany).

01 January 2014

Nicolas joined the lab for his Master 2 training period. He will work with Laure on the effectors delivered by the T6SS in enteroaggregative E. coli.

News & events

  • 06 May 20228 May 2022 - 13 h 03 min
  • 28 April 202228 April 2022 - 17 h 27 min
  • 13-21 February 20222 March 2022 - 11 h 14 min
  • 20 March 202226 March 2022 - 11 h 13 min

Publications

  • T9SS cryo-ET26 April 2022 - 10 h 52 min
  • GldLM Motor25 March 2022 - 21 h 39 min
  • T9SS JDR Review21 November 2021 - 16 h 23 min
  • PorW-Sov interaction12 January 2022 - 16 h 21 min

Contact

CNRS – UMR7255
31 Chemin Joseph Aiguier
13402 Marseille Cedex 20
France

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