EF-Tu-targeting toxin

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Jurenas D, Rey M, Byrne D, Chamot-Rooke J, Terradot L, Cascales E.. 2022. Salmonella antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of EF-Tu P-loop. Nucleic Acids Res. 50, 13114-13127.

PMID: 36484105

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Bacillus T7SS YukC

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Tassinari M, Doan T, Bellinzoni M, Chabalier M, Ben-Assaya M, Martinez M, Gaday Q, Alzari PM, Cascales E, Fronzes R, Gubellini F. 2022. The antibacterial type VII secretion system of Baciluus subtilis: structure and interactions of the pseudokinase YukC/EssB. mBio. 13, e0013422.

PMID: 36154281

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T9SS cryo-ET

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Song L., Perpich J.D., Wu C.G., Doan T., Nowakowska Z., Potempa J. Christie P.J., Cascales E., Lamont R. Hu B. 2022. A unique bacterial secretion machinery with multiple secretion centers. Proc Natl Acad Sci USA. 119, e2119907119.

PMID: 35471908

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This study and the work on the GldLM molecular motor have been featured on the CNRS website (in French): le T9SS, une mitrailleuse à 8 canons !

GldLM Motor

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Vincent M.S., Comas Hervada C., Sebban-Kreuzer C., Le Guenno H., Chabalier M., Kosta A., Guerlesquin F., Mignot T., McBride M.J., Cascales E., Doan T. 2022. Dynamic proton-dependent motors power type IX secretion and gliding motility in Flavobacterium. PLOS Biology. in press

PMID: 35333857

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T9SS JDR Review

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Veith P.D., Glew M.D., Gorasia D.G., Cascales E., Reynolds E.C. 2022. The T9SS system and its role in bacterial function and pathogenesis. J Dent Res. 101, 374-383.

PMID: 34889148

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PorW-Sov interaction

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Gorasia D.G., Lunar Silva I., Butler C.A., Chabalier M., Doan T., Cascales E., Veith P.D., Reynolds E.C. 2022. Protein interactome analysis of the type IX secretion system identifies PorW as the missing link between the PorK/N ring complex and the Sov translocon. Microbiol. Spectrum. 10, e0160221.

PMID: 35019767

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PorN structure

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Fuchsbauer O., Lunar Silva I., Cascales E., Roussel A., Leone P. 2022. Structural and functional analyses of the Porphyromonas gingivalis type IX secretion system PorN protein. J Biol Chem. 298, 101618.

PMID: 35065963

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TiM Spotlight

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Jurenas D., Cascales E. 2022. T6SS: killing two bugs with one stone. Trends Microbiol. 30, 1-2.
Commentary on Le et al. Proc Natl Acad Sci USA. 118, e2106555118.

PMID: 34753653

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