EF-Tu-targeting toxin

Jurenas D, Rey M, Byrne D, Chamot-Rooke J, Terradot L, Cascales E.. 2022. Salmonella antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of EF-Tu P-loop. Nucleic Acids Res. 50, 13114-13127.

PMID: 36484105

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Bacillus T7SS YukC

Tassinari M, Doan T, Bellinzoni M, Chabalier M, Ben-Assaya M, Martinez M, Gaday Q, Alzari PM, Cascales E, Fronzes R, Gubellini F. 2022. The antibacterial type VII secretion system of Baciluus subtilis: structure and interactions of the pseudokinase YukC/EssB. mBio. 13, e0013422.

PMID: 36154281

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T9SS cryo-ET

Song L., Perpich J.D., Wu C.G., Doan T., Nowakowska Z., Potempa J. Christie P.J., Cascales E., Lamont R. Hu B. 2022. A unique bacterial secretion machinery with multiple secretion centers. Proc Natl Acad Sci USA. 119, e2119907119.

PMID: 35471908

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This study and the work on the GldLM molecular motor have been featured on the CNRS website (in French): le T9SS, une mitrailleuse à 8 canons !

GldLM Motor

Vincent M.S., Comas Hervada C., Sebban-Kreuzer C., Le Guenno H., Chabalier M., Kosta A., Guerlesquin F., Mignot T., McBride M.J., Cascales E., Doan T. 2022. Dynamic proton-dependent motors power type IX secretion and gliding motility in Flavobacterium. PLOS Biology. in press

PMID: 35333857

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PorW-Sov interaction

Gorasia D.G., Lunar Silva I., Butler C.A., Chabalier M., Doan T., Cascales E., Veith P.D., Reynolds E.C. 2022. Protein interactome analysis of the type IX secretion system identifies PorW as the missing link between the PorK/N ring complex and the Sov translocon. Microbiol. Spectrum. 10, e0160221.

PMID: 35019767

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PorN structure

Fuchsbauer O., Lunar Silva I., Cascales E., Roussel A., Leone P. 2022. Structural and functional analyses of the Porphyromonas gingivalis type IX secretion system PorN protein. J Biol Chem. 298, 101618.

PMID: 35065963

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