The T6SS is on the cover of the November issue of Journal of Molecular Biology !

ClpV-TssC interaction

Douzi B., Brunet Y.R.,  Spinelli S., Lensi V., Legrand P., Blangy S., Kumar A., Journet L., Cascales E. & Cambillau C. 2016. Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli. Sci Rep. 6, 34405.

PMID: 27698444

see more >

TssLc domain

Zoued A., Cassaro C.J., Durand E., Douzi B., Espana A.P., Cambillau C., Journet L. & Cascales E.  2016. Structure-function analysis of the TssL cytoplasmic domain reveals a new interaction beween the Type VI secretion baseplate and membrane complexes. J Mol Biol. 428, 4413-4423.

PMID: 27600409

see more >

TssMc domain

Logger L., Aschtgen M.S., Guérin M., Cascales E. & Durand E.  2016. Molecular dissection of the interface between the Type VI secretion TssM cytoplasmic domain and the TssG baseplate component. J Mol Biol. 428, 4424-4437.

PMID: 27600411

see more >


Vincent M.S., Durand E. & Cascales E.  2016. The PorX response regulator of the Porphyromonas gingivalis PorXY two-component system does not directly regulate the Type IX secretion genes but binds the PorL subunit. Front Cell Infect Microbiol. 6, 96.

PMID: 27630829

see more >

Salmonella Attacks !

Sana T., Flaugnatti N., Lugo K.A., Lam L.L., Jacobson A., Baylot V., Durand E., Journet L., Cascales E. & Monack D.M. 2016. S. Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut. Proc Natl Acad Sc. USA. 113, 5044-5051.

PMID: 27503894

see more >

see the CNRS press release here

This article has been recommended by Eugene Nester on F1000

TssA is a tail coordinator

Zoued A., Durand E., Brunet Y.R., Spinelli S., Douzi B., Guzzo M., Flaugnatti N., Legrand P., Journet L., Fronzes R., Mignot T., Cambillau C. & Cascales E. 2016. Priming and polymerization of a bacterial contractile tail. Nature. 531, 59-63.

PMID: 26909579

see more >

see the CNRS press release here

This article has been recommended by Chris Whitfield on F1000

T6SS phospholipase effector

Flaugnatti N., Le TT., Canaan S., Aschtgen MS., Nguyen VS., Blangy S., Kellenberger C., Roussel A., Cambillau C., Cascales E. & Journet L. 2016. A phospholipase A1 antibacterial type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery. Mol Microbiol. 99, 1099-1118.

PMID: 26714038

see more >