Cover
The T6SS is on the cover of the November issue of Journal of Molecular Biology !
The T6SS LTG
Santin Y.G. & Cascales E. 2017. Domestication of a housekeeping transglycosylase for assembly of a Type VI secretion system. EMBO Rep. 18, 138-149.
ClpV-TssC interaction
Douzi B., Brunet Y.R., Spinelli S., Lensi V., Legrand P., Blangy S., Kumar A., Journet L., Cascales E. & Cambillau C. 2016. Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli. Sci Rep. 6, 34405.
TssLc domain
Zoued A., Cassaro C.J., Durand E., Douzi B., Espana A.P., Cambillau C., Journet L. & Cascales E. 2016. Structure-function analysis of the TssL cytoplasmic domain reveals a new interaction beween the Type VI secretion baseplate and membrane complexes. J Mol Biol. 428, 4413-4423.
TssMc domain
Logger L., Aschtgen M.S., Guérin M., Cascales E. & Durand E. 2016. Molecular dissection of the interface between the Type VI secretion TssM cytoplasmic domain and the TssG baseplate component. J Mol Biol. 428, 4424-4437.
PorXY TCS
Vincent M.S., Durand E. & Cascales E. 2016. The PorX response regulator of the Porphyromonas gingivalis PorXY two-component system does not directly regulate the Type IX secretion genes but binds the PorL subunit. Front Cell Infect Microbiol. 6, 96.
Salmonella Attacks !
Sana T., Flaugnatti N., Lugo K.A., Lam L.L., Jacobson A., Baylot V., Durand E., Journet L., Cascales E. & Monack D.M. 2016. S. Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut. Proc Natl Acad Sc. USA. 113, 5044-5051.
see the CNRS press release here
This article has been recommended by Eugene Nester on F1000
TssA is a tail coordinator
Zoued A., Durand E., Brunet Y.R., Spinelli S., Douzi B., Guzzo M., Flaugnatti N., Legrand P., Journet L., Fronzes R., Mignot T., Cambillau C. & Cascales E. 2016. Priming and polymerization of a bacterial contractile tail. Nature. 531, 59-63.
PMID: 26909579
see the CNRS press release here
This article has been recommended by Chris Whitfield on F1000
Baeza meeting report
Aussel L., Beuzón C.R., & Cascales E. 2016. Meeting report: adaptation and communication of bacterial pathogens. Virulence. 7, 481-490.
PMID: 26890494
T6SS phospholipase effector
Flaugnatti N., Le TT., Canaan S., Aschtgen MS., Nguyen VS., Blangy S., Kellenberger C., Roussel A., Cambillau C., Cascales E. & Journet L. 2016. A phospholipase A1 antibacterial type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery. Mol Microbiol. 99, 1099-1118.
PMID: 26714038
