Baeza meeting report
Aussel L., Beuzón C.R., & Cascales E. 2016. Meeting report: adaptation and communication of bacterial pathogens. Virulence. 7, 481-490.
PMID: 26890494
T6SS phospholipase effector
Flaugnatti N., Le TT., Canaan S., Aschtgen MS., Nguyen VS., Blangy S., Kellenberger C., Roussel A., Cambillau C., Cascales E. & Journet L. 2016. A phospholipase A1 antibacterial type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery. Mol Microbiol. 99, 1099-1118.
PMID: 26714038
EcoSal
Journet L., & Cascales E. 2016. The Type VI secretion system in Escherichia coli and related species. EcoSalPlus. 7, 1-20.
T6SS baseplate identification
Brunet Y.R., Zoued A., Boyer F., Douzi B. & Cascales E. 2015. The Type VI secretion TssEFGK-VgrG phage-like baseplate is recruited to the TssJLM membrane complex via multiple contacts and serves as assembly platform for tail tube/sheath polymerization. PLOS Genetics. 11, e1005545.
Biogenesis and structure of the T6SS membrane complex
Durand E., Nguyen V.S., Zoued A., Logger L., Pehau-Arnaudet G., Aschtgen M.S., Spinelli S., Desmyter A. Bardiaux B., Roussel A., Cambillau C., Cascales E. & Fronzes R. 2015. Biogenesis and structure of a Type VI secretion core membrane complex. Nature. 523, 555-560.
see the CNRS press release here
H-NS regulation of Salmonella T6SS
Brunet Y.R., Khodr A., Logger L., Aussel L., Mignot T., Rimsky S., and Cascales E. 2015. H-NS silencing of the SPI-6-encoded Type VI secretion system limits Salmonella enterica serovar Typhimurium interbacterial killing. Infect Immun. 83, 2738-2750.
TssM-specific nanobody competes with T6SS
Nguyen VS, Logger L., Spinelli S., Desmyter A., Han Lè TT, Kellenberger C., Douzi B., Durand E., Roussel A., Cascales E., and Cambillau C. 2015. Inhibition of Type VI secretion by an anti-TssM llama nanobody. PLOS ONE. 10, e0122187.
TssM-specific nanobodies
Nguyen VS, Spinelli S., Desmyter A., Han Lè T.T., Kellenberger C., Cascales E., Cambillau C. and Roussel A. 2015. Production, crystallization and X-ray diffraction analysis of a complex between a fragment of the TssM T6SS protein and a camelid antibody. Acta Crystallogr F Struct Biol Commun. 71, 266-271.
PorM crystallization
Stathopulos J., Cambillau C., Cascales E., Roussel A. and Leone P. 2015. Crystallization and preliminary X-ray analysis of the C-terminal fragment of PorM, a subunit of the Porphyromonas gingivalis Type IX secretion system. Acta Crystallogr F Struct Biol Commun. 71, 71-74.
PLoS Genetics 2014 e1004869.
Gueguen E., Wills N.M., Atkins J.A., and Cascales E. 2014. Transcriptional frameshiting rescues Citrobacter rodentium Type VI secretion by the production of two length variants from the prematurely interrupted tssM gene. PLoS Genetics. 10, e1004869.
