T6SS baseplate wedge

Cherrak Y., Rapisarda C., Pellarin R., Bouvier G., Bardiaux B., Allain F. Malosse C., Rey M., Chamot-Rooke J., Cascales E., Fronzes R., Durand E. 2018. Biogenesis and structure of a Type VI secretion baseplate. Nat. Microbiol. 3, 1404-1416 .

PMID: 30323254

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see the Behind the paper  “Building the blocks of a bacterial weapon” by Chiara.


Santin Y.G., Doan T., Lebrun R., Espinosa L., Journet L., Cascales E. 2018. In vivo proximity labelling during Type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheath. Nat. Microbiol. 3, 1304-1313 .

PMID: 30275513

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see the Behind the paper  “The Type VI secretion system under tension” by Yoann.

see the CNRS press release here

see the News and Views “Tagging the Type VI secretion system” by Olivera Francetic.


Renault M.G., Zamarreno Beas J., Douzi B., Chabalier M. Zoued A., Brunet Y.R., Cambillau C., Journet L., Cascales E. 2018. The gp27-like hub of VgrG serves as adaptor to promote Hcp tube assembly. J. Mol. Biol. 430, 3143-3156.

PMID: 30031895

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Zoued A., Duneau J.P., Durand E., Espana A.P., Journet L., Guerlesquin F., Cascales E. 2018. Tryptophan-mediated dimerization of the TssL transmembrane anchor is required for Type VI secretion system activity. J. Mol. Biol. 430, 987-1003.

PMID: 29458124

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Review COSB

Nguyen V.S., Douzi B., Durand E., Roussel A., Cascales E., Cambillau C. 2018. Towards a complete structural deciphering of Type VI secretion system. Curr. Opin. Struct. Biol. 49, 77-84.

PMID: 29414515

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PorM structure

Leone P., Roche J., Vincent M.S., Tran Q.H., Desmyter A., Cascales E., Kellenberger C., Cambillau C., Roussel A. 2018. Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasm space. Nat. Commun. 9, 429.

PMID: 29382829

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JMB TssB Cter

Douzi B., Logger L., Spinelli S., Blangy S., Cambillau C., Cascales E. 2018. Structure-function analysis of the C-terminal domain of the Type VI secretion TssB tail sheath subunit. J. Mol. Biol. 430, 297-309.

PMID: 29223729

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