Cover

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The T6SS is on the cover of the November issue of Nature Microbiology.

T6SS baseplate wedge

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Cherrak Y., Rapisarda C., Pellarin R., Bouvier G., Bardiaux B., Allain F. Malosse C., Rey M., Chamot-Rooke J., Cascales E., Fronzes R., Durand E. 2018. Biogenesis and structure of a Type VI secretion baseplate. Nat. Microbiol. 3, 1404-1416 .

PMID: 30323254

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see the Behind the paper  “Building the blocks of a bacterial weapon” by Chiara.

APEX-TagA

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Santin Y.G., Doan T., Lebrun R., Espinosa L., Journet L., Cascales E. 2018. In vivo proximity labelling during Type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheath. Nat. Microbiol. 3, 1304-1313 .

PMID: 30275513

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see the Behind the paper  “The Type VI secretion system under tension” by Yoann.

see the CNRS press release here

see the News and Views “Tagging the Type VI secretion system” by Olivera Francetic.

Hcp-VgrG

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Renault M.G., Zamarreno Beas J., Douzi B., Chabalier M. Zoued A., Brunet Y.R., Cambillau C., Journet L., Cascales E. 2018. The gp27-like hub of VgrG serves as adaptor to promote Hcp tube assembly. J. Mol. Biol. 430, 3143-3156.

PMID: 30031895

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TssL-TM

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Zoued A., Duneau J.P., Durand E., Espana A.P., Journet L., Guerlesquin F., Cascales E. 2018. Tryptophan-mediated dimerization of the TssL transmembrane anchor is required for Type VI secretion system activity. J. Mol. Biol. 430, 987-1003.

PMID: 29458124

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Review TiM

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Chassaing B.,  Cascales E. 2018. Antibacterial weapons: targeted destruction in the microbiota. Trends Microbiol. 26, 329-338.

PMID: 29452951

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Review COSB

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Nguyen V.S., Douzi B., Durand E., Roussel A., Cascales E., Cambillau C. 2018. Towards a complete structural deciphering of Type VI secretion system. Curr. Opin. Struct. Biol. 49, 77-84.

PMID: 29414515

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PorM structure

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Leone P., Roche J., Vincent M.S., Tran Q.H., Desmyter A., Cascales E., Kellenberger C., Cambillau C., Roussel A. 2018. Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasm space. Nat. Commun. 9, 429.

PMID: 29382829

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JMB TssB Cter

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Douzi B., Logger L., Spinelli S., Blangy S., Cambillau C., Cascales E. 2018. Structure-function analysis of the C-terminal domain of the Type VI secretion TssB tail sheath subunit. J. Mol. Biol. 430, 297-309.

PMID: 29223729

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