T6SS baseplate identification

Brunet Y.R., Zoued A., Boyer F., Douzi B. & Cascales E. 2015. The Type VI secretion TssEFGK-VgrG phage-like baseplate is recruited to the TssJLM membrane complex via multiple contacts and serves as assembly platform for tail tube/sheath polymerization. PLOS Genetics. 11, e1005545.

PMID: 26460929

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Biogenesis and structure of the T6SS membrane complex

Durand E., Nguyen V.S., Zoued A., Logger L., Pehau-Arnaudet G., Aschtgen M.S., Spinelli S., Desmyter A. Bardiaux B., Roussel A., Cambillau C., Cascales E. & Fronzes R. 2015. Biogenesis and structure of a Type VI secretion core membrane complex. Nature. 523, 555-560.

PMID: 26200339

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see the CNRS press release here

H-NS regulation of Salmonella T6SS

Brunet Y.R., Khodr A., Logger L., Aussel L., Mignot T., Rimsky S., and Cascales E. 2015. H-NS silencing of the SPI-6-encoded Type VI secretion system limits Salmonella enterica serovar Typhimurium interbacterial killing. Infect Immun. 83, 2738-2750.

PMID: 25916986

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TssM-specific nanobody competes with T6SS

Nguyen VS, Logger L., Spinelli S., Desmyter A., Han Lè TT, Kellenberger C., Douzi B., Durand E., Roussel A., Cascales E., and Cambillau C. 2015. Inhibition of Type VI secretion by an anti-TssM llama nanobody. PLOS ONE. 10, e0122187.

PMID: 25811612

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TssM-specific nanobodies

Nguyen VS, Spinelli S., Desmyter A., Han Lè T.T., Kellenberger C., Cascales E., Cambillau C. and Roussel A. 2015. Production, crystallization and X-ray diffraction analysis of a complex between a fragment of the TssM T6SS protein and a camelid antibody. Acta Crystallogr F Struct Biol Commun. 71, 266-271.

PMID: 25760699

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PorM crystallization

Stathopulos J., Cambillau C., Cascales E., Roussel A. and Leone P. 2015. Crystallization and preliminary X-ray analysis of the C-terminal fragment of PorM, a subunit of the Porphyromonas gingivalis Type IX secretion system. Acta Crystallogr F Struct Biol Commun. 71, 71-74.

PMID: 25615973

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